Almost all the allergenic extracts recorded negative in the skin test gave a positive IgE test in vitro. Prevalence further increased in subsets with multiple pollen sensitization (71%), and with a previous pollen immunotherapy course (46%), whereas minor differences were found in gender and age distribution. Prevalence varied when subsets of non-allergic (5%), non-pollen-allergic (10%), and pollen-allergic (31%) subjects were considered. To find out whether a glycoprotein is capable of triggering an allergic reaction, 1,076 subjects were also skin tested with several purified molecules bearing carbohydrate side chains differing in number, composition and complexity.Īn overall prevalence of 23% of positive IgE to cross-reacting carbohydrate determinants was recorded. Data were analysed on the basis of demographical and allergological parameters. In previous studies we showed how the presence of IgE to bromelain could be a useful and simple marker of the presence of IgE to carbohydrate epitopes.Ī survey of 1,831 subjects with a suspected allergic respiratory disease has been carried out by detecting IgE to bromelain. IgE to cross-reacting carbohydrate determinants has already been described by several authors, but their function and distribution are still a matter of debate.
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